Action of Disodium Ethylenediamine Tetracetate on Blood Coagulation

Action of disodium ethylenediamine tetracetate on blood coagulation; evidence of the development of heparinoid activity during incubation or aeration of plasma.

T LIE ANTICOA(.ULANT PROPERTIES OF ethyleimediamine tetracetic acid were studied for the first time by 1)yckerhoff amid his co-workers.’ They comicluded that this compoumnd acted mainly as ami ant.ithrombin amid to a lesser degree as an antiprothrombin. Later Bosenfeld amid Jansky’ reported that disodiuim ethvlemiediamimie tetracetate or Ei)TA inhibits the tramisformatiomi of fibrinogen to fibr...

The Mechanism of the Action of Saliva in Blood Coagulation

It is well known that the addition of saliva to blood will accelerate its coagulation (1, 2, 7). This property of saliva is not species specific. It has been shown that dog, cat and human saliva will indiscriminately accelerate the clotting of blood obtained from the dog, cat, cow or man (1, 7). Bellis, Birnbaum and Scott (1) noted that while the clotting factor of saliva was stable at 60 " , i...

Studies on Blood Coagulation

Although calcium is essential for the formation of thrombin, it can be recovered quantitatively from formed horse thrombin without affecting its coagulating activity. Citrate also has no significant effect. As stated in the text, this does not exclude the possibility that thrombin is actually a calcium compound present in minute concentration; but confirming the results of Hammarsten, it does s...

Lipids of Human Platelets and Their Action on the Blood Coagulation Process.

M ANY WORKERS have shown that phospholipids accelerate in vitro coagulation of blood. Recent advances in the methods of total lipid extraction13 and in chromatographic3’4 and countercurrent distribution5 technics for the separation of lipid classes have intensified interest in the identification of the specific lipid moieties of platelets which accelerate the blood coagulation process. In the p...

Effect of exercise on blood coagulation.